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iGen™ is a collagen implant, and is a biodegradable scaffold which can induce a regenerative non-scarring wound healing process without the use of medicine. This collagen implant improves the remodeling of the regenerating tissue and prevents scar formation. As stated, iGen™ is used not only for trabeculectomy, but also other ophthalmic surgeries, such as pterygium removal, rejuvenation of ocular tissue for presbyopia, oculoplastic surgery and veterinary surgery.

1. iGen™ in Glaucoma Applications
For glaucoma applications, ophthalmologists simply operate using the standard procedure for trabeculectomy and simply implanting iGen™ on the top of the scleral flap under the conjunctiva before suturing. The trabeculectomy procedure using the iGen™ implant can ensure a more than 95% success rate without the application of anti-fibrotic or anti-proliferative agents.

The principal of the iGen™ collagen implant is to induce fibroblast to grow randomly, which leads to the wound healing normally. The iGen™ scaffold's porous structure can work as a reservoir, a buffering system, and a controlled drainage solution. It randomizes the growth of myofibroblasts and creates a new physiological environment between the anterior chamber and subconjunctival space of the eyeball. iGen™ maintains the physiological barrier by regeneration which maintains both the function of the bleb and normalizes the dynamic aqueous balance to create a safe conjunctival system.

2. iGen™ in Presbyopia Treatment
iGen™ application in presbyopia treatment helps to generate low density ocular tissue instead of scar tissue. The procedure results in a more elastic ocular tissue and leads to better accommodation ability for the presbyopic eye.

3. iGen™ in Other Applications
• Pterygium surgery (reduces recurrence)
• Failed trabeculectomy
• Neovascular glaucoma
• Inadequate conjunctiva: Severe conjunctival scarring following surgery
• Impending need for PKP
• iGen™ replaces the need for expensive GDDs and anti-fibrotic agents particularly important for developing countries
• Glaucoma with uveitis
• Primary trabeculectomy
• Nasolacrimal duct surgery (prevents scar formation)
• Orbital surgery
• Eye plastic
• Chemical burns